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10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Topiramate in migraine progression
1SOC Neurologia-Azienda Ospedaliera SS. Antonio e Biagio, via Venezia 16, Alessandria, Italy. lruiz@ospedale.al.it
The Journal of Headache and Pain
|October 20, 2009
Summary
Topiramate is an effective neuromodulator for preventing and treating migraine, including chronic forms. Early intervention with topiramate may prevent migraine progression and reduce medication overuse.
Area of Science:
- Neurology
- Neuroscience
- Pharmacology
Background:
- Migraine is increasingly recognized as a chronic and potentially progressive neurological disorder.
- Subclinical brain changes and altered pain perception in migraineurs may contribute to disease progression.
- Topiramate is a well-established neuromodulator for migraine prevention with a high level of evidence-based efficacy.
Purpose of the Study:
- To review the evidence for topiramate's efficacy in preventing episodic migraine and treating chronic migraine.
- To explore topiramate's mechanisms of action in stabilizing neuronal activity and reducing hyperexcitability.
- To assess topiramate's role in preventing the transformation of episodic to chronic migraine and managing medication-overuse headache.
Main Methods:
- Review of existing literature and recent multicenter, randomized, placebo-controlled trials.
- Analysis of topiramate's pharmacological mechanisms, including neuronal stabilization and reduction of cortical hyperexcitability.
- Evaluation of clinical trial data on topiramate's effectiveness in reducing migraine frequency and acute medication use.
Main Results:
- Topiramate demonstrates efficacy in reducing migraine frequency in episodic migraine.
- Treatment with topiramate 100 mg/day is effective and well-tolerated in patients with chronic migraine and medication-overuse.
- Topiramate may prevent the negative progression of migraine by reducing attack frequency and acute medication use.
Conclusions:
- Topiramate is a valuable preventive treatment for migraine, acting at multiple levels of the migraine cycle.
- Early and sustained topiramate treatment may reduce the risk of migraine chronification.
- Topiramate offers a therapeutic option for difficult-to-treat chronic migraine and medication-overuse conditions.
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