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Related Experiment Video

Updated: Jun 19, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Extremity soft tissue sarcomas presented as hematomas.

Vasileios A Kontogeorgakos¹, Salutario Martinez, Leslie Dodd

¹Section of Orthopaedic Oncology, Department of Orthopaedic Surgery, Duke University, Durham, NC 27710, USA. vaskonto@gmail.com

Archives of Orthopaedic and Trauma Surgery

|October 20, 2009

Summary

This summary is machine-generated.

Soft tissue sarcoma (STS) mimicking hematoma is often misdiagnosed, leading to delayed treatment and poor outcomes. Early suspicion and pathological examination are crucial for timely diagnosis and improved prognosis in these challenging cases.

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Last Updated: Jun 19, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

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Published on: July 28, 2020

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

Area of Science:

Oncology
Pathology
Radiology

Background:

Soft tissue sarcoma (STS) with hemorrhage is rarely described and often misdiagnosed as hematoma.
Outcomes for patients with hemorrhagic STS have not been previously detailed.

Purpose of the Study:

To describe the clinical presentation, diagnostic challenges, and outcomes of patients with high-grade STS initially misdiagnosed as hematoma.

Main Methods:

Retrospective review of 15 patients with initial diagnosis of hematoma or hemorrhagic sarcoma.
Analysis of clinical data, imaging, biopsy results, treatment, and patient outcomes.

Main Results:

Thigh was the most common location; 3 patients had bleeding predisposition.
Delayed diagnosis was common, with a mean of 7 months for patients requiring two biopsies.
Eight of nine patients developed lung metastases within a median of 7 months, indicating a dismal prognosis.

Conclusions:

STS should be suspected if trauma severity is disproportionate to injury or if lesions don't resolve with conservative management.
Bleeding predisposition does not rule out malignancy; hematoma evacuation should include pathological examination.
Early metastatic disease significantly impacts prognosis, highlighting the need for prompt diagnosis.