Related Experiment Video
Updated: Jun 19, 2026
06:34
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
[Isolated left ventricular non-compaction - various clinical presentations].
Janina Aleszewicz-Baranowska1, Joanna Kwiatkowska, Piotr Potaz
1Klinika Kardiologii Dzieciecej iWad Wrodzonych Serca, Gdański Uniwersytet Medyczny. jalesz@amg.gda.pl
Kardiologia Polska
|October 20, 2009
Summary
Isolated left ventricular non-compaction (LVNC) is a heart muscle disorder from defective endomyocardial morphogenesis. This condition leads to significant risks of thromboembolism, heart failure, and arrhythmias.
Area of Science:
- Cardiology
- Developmental Biology
- Genetics
Background:
- Isolated left ventricular non-compaction (LVNC) is a congenital myocardial disorder.
- It arises from abnormal endomyocardial development during embryogenesis.
- LVNC is increasingly diagnosed, highlighting its clinical significance.
Observation:
- The study presents three distinct clinical cases of LVNC.
- These cases illustrate the varied presentations of the disorder.
- Detailed clinical information for each case is provided.
Findings:
- LVNC is characterized by a spongy myocardium with prominent trabeculations.
- Associated complications include thromboembolism, heart failure, and cardiac arrhythmias.
- The specific genetic and etiological factors may vary between cases.
Implications:
- Understanding LVNC's varied clinical pictures is crucial for timely diagnosis and management.
- Early identification can mitigate risks of severe cardiac events.
- Further research into LVNC pathogenesis may reveal targeted therapeutic strategies.
Related Concept Videos
01:26Heart Failure III: Clinical Manifestations
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:25Cardiomyopathy I: Introduction and Classification
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
01:30Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...