Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digital phenotyping with large language models to detect depressive state changes in patients.

NPJ digital medicine·2026
Same author

Self-reported antidepressant side effects in psychiatric patients with depressive disorders.

Nordic journal of psychiatry·2026
Same author

Variability in self-reported depression symptomology and associated behavioral markers in digital phenotyping.

Scientific reports·2026
Same author

Effectiveness of guided self-help, guided internet-delivered cognitive behavioral therapy, and face-to-face cognitive behavioral therapy for depression and anxiety: protocols of four parallel randomized controlled non-inferiority trials of the Finnish First-Line Therapies -Initiative (FLT-Step).

BMC psychiatry·2026
Same author

Examining the factor structure of the 40-item Defense Style Questionnaire among adults with depression: an individual participant data meta-analysis.

Research in psychotherapy (Milano)·2026
Same author

Study protocol for a randomised controlled trial of dance-movement therapy for adolescents with depression.

BMC psychology·2026

Related Experiment Video

Updated: Jun 19, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

[Update on current care guidelines. Depression, current care guideline].

Erkki Isometsä, Pekka Jousilahti, Olavi Lindfors

    Duodecim; Laaketieteellinen Aikakauskirja
    |October 21, 2009
    PubMed
    Summary

    Effective depression treatment involves diagnosis, psychotherapy for mild to moderate cases, and medication or electroconvulsive therapy (ECT) for severe depression. Maintenance treatment prevents relapse, with primary care managing most cases.

    More Related Videos

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
    04:33

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

    Published on: April 26, 2024

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
    10:54

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

    Published on: November 21, 2025

    Related Experiment Videos

    Last Updated: Jun 19, 2026

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
    04:29

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

    Published on: January 7, 2019

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
    04:33

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

    Published on: April 26, 2024

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
    10:54

    Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

    Published on: November 21, 2025

    Area of Science:

    • Psychiatry and Mental Health
    • Clinical Psychology
    • Pharmacology

    Context:

    • Depression treatment requires accurate diagnosis and tailored therapeutic approaches.
    • Mild to moderate depression often responds to brief psychotherapies.
    • Severe or psychotic depression necessitates more intensive interventions.

    Purpose:

    • To outline effective treatment strategies for depression based on diagnostic evaluation and severity.
    • To detail the role of psychotherapy, antidepressants, and electroconvulsive therapy (ECT).
    • To emphasize the importance of maintenance treatment and the role of primary healthcare.

    Summary:

    • Treatment selection for depression depends on diagnostic evaluation and symptom severity.
    • Psychotherapies are effective for mild to moderate depression, while antidepressants and ECT are crucial for more severe forms.
    • Post-acute treatment includes a minimum of six months of antidepressants to prevent relapse, with maintenance therapy recommended after three episodes.

    Impact:

    • Provides a clear framework for managing depression across different severity levels.
    • Highlights the importance of continued treatment to prevent depressive episodes.
    • Underscores the collaborative role of primary care and specialist psychiatric services.