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Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
Olfaction01:25

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Related Experiment Video

Updated: Jun 19, 2026

Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording
09:51

Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording

Published on: March 2, 2010

Olfactory dysfunction in Wegener's granulomatosis.

M Laudien, P Lamprecht1, J Hedderich

  • 1University of Lübeck, Department of Rheumatology, Vasculitis Center UKSH & Rheumaklinik Bad Bramstedt, Lübeck, Germany.

Rhinology
|October 21, 2009
PubMed
Summary
This summary is machine-generated.

Wegener's granulomatosis (WG) patients experience olfactory dysfunction, confirmed by psychophysiological tests. This dysfunction is linked to mupirocin use and disease duration, not other factors.

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Related Experiment Videos

Last Updated: Jun 19, 2026

Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording
09:51

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Published on: March 2, 2010

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice
08:42

Whole Mount Labeling of Cilia in the Main Olfactory System of Mice

Published on: December 27, 2014

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice
04:00

Studying the Effects of Inhaled Environmental Pollutants on Olfactory Function in Mice

Published on: September 13, 2024

Area of Science:

  • Otolaryngology
  • Immunology
  • Neurology

Background:

  • Wegener's granulomatosis (WG) involves upper respiratory tract inflammation, potentially causing olfactory dysfunction.
  • Previous studies lacked systematic olfactory testing in WG patients.
  • The precise mechanisms of olfactory impairment in WG remain unclear.

Purpose of the Study:

  • To systematically evaluate olfactory function in WG patients using modern psychophysiological tools.
  • To investigate potential correlations between olfactory dysfunction and clinical parameters in WG.

Main Methods:

  • Seventy-six WG patients underwent olfactory testing using the Sniffin' Sticks 12 (TDI score).
  • Active anterior rhinomanometry and a standardized olfactory function questionnaire were employed.
  • Data were analyzed for correlations with clinical variables.

Main Results:

  • WG patients demonstrated significantly altered olfactory function compared to normative data.
  • Olfactory dysfunction was significantly correlated with topical mupirocin administration.
  • A significant correlation was also found between olfactory dysfunction and the time from WG diagnosis to study entry.
  • No other tested variables showed a statistically significant effect on olfactory function.

Conclusions:

  • WG patients are aware of their olfactory deficits, which are objectively measurable.
  • Topical mupirocin treatment and disease duration are significant factors associated with olfactory dysfunction in WG.
  • Further research is needed to elucidate the complex relationship between WG and olfactory processing.