Related Experiment Video
Updated: Jun 19, 2026

Analyzing Responses of Mouse Olfactory Sensory Neurons Using the Air-phase Electroolfactogram Recording
Published on: March 2, 2010
Olfactory dysfunction in Wegener's granulomatosis
M Laudien, P Lamprecht1, J Hedderich
1University of Lübeck, Department of Rheumatology, Vasculitis Center UKSH & Rheumaklinik Bad Bramstedt, Lübeck, Germany.
Abstract:
Necrotizing granulomatous inflammation of the upper respiratory tract is one of the hallmarks of Wegener's granulomatosis (WG), which may explain the reason for olfactory dysfunction in WG. However, a systematic analysis using modem olfactory testing tools has not been performed and potential causes of dysfunction at different levels of olfactory information processing remain obscure so far. In this study a group of 76 WG-patients was examined with sniffin'sticks screening 12, odour threshold (T)/discrimination (D)/identification (I) TDI-score, active anterior rhinomanometry and a standardized questionnaire for olfactory function. WG-patients were aware of their olfactory dysfunction, as proven by psychophysiological test results. An altered olfactory function was significantly correlated to local administration of mupirocin and to the time interval between first diagnosis and study entry. None of the other variables had a statistical significant effect on the olfactory dysfunction.
Related Concept Videos
Olfactory Receptors: Location and Structure
Physiology of Smell and Olfactory Pathway
The olfactory...
Olfaction
The olfactory receptors are embedded in the cilia of the...
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...

