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[Vesicoureteric reflux: it all depends on the genes?]

Andrzej Brodkiewicz1, Anna Zakowska, Agnieszka Bińczak-Kuleta

  • 1Klinika Pediatrii, Hematologii i Onkologii Dzieciecej Pomorskiej Akademii Medycznej w Szczecinie, Szczecin.

Annales Academiae Medicae Stetinensis
|October 21, 2009
PubMed

Insights

Vesicoureteric reflux (VUR) in children is a significant health issue often linked to genetics. Research highlights candidate genes playing a key role in the development of this condition, impacting urinary tract infections and kidney function.

Area of Science:

  • Pediatric Nephrology
  • Medical Genetics
  • Urology

Context:

  • Vesicoureteric reflux (VUR) involves reversed urine flow from the bladder to ureters and kidneys.
  • It is associated with ureterovesical junction abnormalities and is a common pediatric concern.
  • VUR contributes to urinary tract infections, reflux nephropathy, and chronic kidney disease in children.

Purpose:

  • To review recent literature on the genetic basis of VUR in children.
  • To highlight the role of candidate genes in VUR development.
  • To underscore the importance of genetic factors in pediatric VUR.

Summary:

  • VUR is an autosomal dominant inherited disease with potential incomplete gene penetration.
  • Recent research confirms a significant genetic background for VUR.
  • Candidate genes are crucial in the pathogenesis of VUR in pediatric populations.

Impact:

  • Understanding the genetic underpinnings of VUR can lead to improved diagnostics.
  • Identifying genetic risk factors may enable earlier intervention and prevention strategies.
  • This knowledge can advance the management of VUR and its associated renal complications in children.

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