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Updated: Jun 19, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
Published on: November 15, 2017
Polymerase chain reaction and immunoassay--matrix assisted laser desorption mass spectrometry using tag-mass
J Stauber1, M El Ayed, M Wisztorski
1University de Lille1, CNRS, MALDI Imaging Team, Laboratoire de Neuroimmunologie des Annélides, Villeneuve d'Ascq F-59655, France.
Abstract:
We present a new development of the Tag-Mass concept based on a photocleavable linker with tagged molecules for polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) quantification coupled to mass spectrometry. PCR-MS and immunosorbent assay-MS with tagged oligonucleotides, bases, and antibodies will allow the acquisition of multiplexed information from genomic, transcriptomic, and proteomic experiments. This is a novel application of Tag-Mass from tissue imaging to fluid quantification and will open doors to several clinical applications ranging from biomarker-driven gene modulation to use at the patient's bedside following treatment.
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