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Updated: Jun 19, 2026

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
Published on: December 20, 2019
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA
Yang Liu1, Eleanor Peacey, John Dickson
1Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School,H.I.M. 754, Boston, Massachusetts 02115, USA.
Abstract:
A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem-loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer's and other neurodegenerative diseases. Several compounds showed significantly improved binding activity relative to the original screening hit mitoxantrone. These findings establish essential structure-activity relationships to further optimize the activity of this promising class of compounds.
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