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Updated: Jun 19, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Preparation and characterization of vitamin-12 loaded biodegradable pH-sensitive microgels
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Chengdu, PR China.
Abstract:
This paper prepared novel biodegradable and pH-sensitive microgels based on Poly(epsilon-caprolactone)-Pluronic-Poly(epsilon-caprolactone)-dimethacrylate (PCFC-DMA), Poly(ethylene glycol) dimethacrylate (PEG-DMA) and methylacrylic acid (MAA) cross-linked with N,N'-methylenebisacrylamide (BIS), initiated by NaHSO(3), K(2)S(2)O(8). The blank microgels were prepared by inversed-phase suspension polymerization method and pH sensitivity of microgels was characterized. Then the blank microgels were loaded with hydrophilic model drug vitamin-12 (VB-12) and in vitro drug release behaviour was also studied here.

