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Published on: June 16, 2020
Graves' disease associated with primary systemic sclerosis
Yves Wimmersberger1, Doris Zuercher
1Hôpital Cantonal Genève, HUG, Clinique d'Ophtalmologie, Switzerland.
Abstract:
Graves' disease can be associated with other autoimmune disorders. Primary systemic sclerosis (PSS) is such a disease characterised by multi-organ fibrosis. Abnormal thyroid antibody titres and hypothyroidism as well as hyperthyroidism have been observed in PSS patients. Specific and idiopathic inflammatory disorders are an important differential diagnosis in Graves'orbitopathy (GO). Mycophenolate mofetil (MM) is an immunosuppressive drug which depletes guanosin nucleotides in proliferating B-and T-lymphocytes. We describe the effect of MM on the endocrine orbitopathy of a patient with PSS.
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