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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents

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Cannabinoids and neurodegenerative diseases.

J Romero¹, J Martínez Orgado

¹Laboratorio de Investigación, Hospital Universitario Fundación Alcorcón and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). C/o Budapest 1. 28922. Alcorcón, Spain. jromerop@fhalcorcon.es

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|October 21, 2009

Summary

Cannabinoids show neuroprotective effects like antioxidant and anti-inflammatory actions. This review explores their potential for treating neurodegenerative diseases such as Alzheimer's and multiple sclerosis.

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Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

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Published on: August 1, 2025

Area of Science:

Neuroscience
Pharmacology

Background:

Despite advances in understanding neurodegenerative diseases, effective treatments remain limited.
The endocannabinoid system (ECS) is being investigated as a novel therapeutic target.
Cannabinoids exhibit known neuroprotective properties.

Purpose of the Study:

To review the therapeutic potential of cannabinoid agents for neurodegenerative diseases.
To explore the mechanisms underlying cannabinoid neuroprotection.

Main Methods:

Literature review of existing data on cannabinoid agents and neurodegenerative diseases.
Analysis of molecular mechanisms of cannabinoid action.

Main Results:

Cannabinoids possess antioxidative, antiglutamatergic, and anti-inflammatory effects.
These properties are relevant to multiple neurodegenerative processes.
Cannabinoids demonstrate potential as therapeutic agents.

Conclusions:

Cannabinoid agents are promising candidates for novel therapeutic strategies in neurodegenerative diseases.
Further research is warranted to develop cannabinoid-based treatments for conditions like Alzheimer's disease, multiple sclerosis, Huntington's disease, and amyotrophic lateral sclerosis.