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Helicobacter pylori infection in children: population-based age-specific prevalence and risk factors in a developing

W Jafri1, J Yakoob, S Abid

  • 1Department of Medicine and Pediatrics, Aga Khan University, Karachi, Pakistan.

Acta Paediatrica (Oslo, Norway : 1992)
|October 21, 2009
PubMed

Insights

Helicobacter pylori seroprevalence in children rises with age and is linked to lower socioeconomic status and parental education. Improving sanitation and education can help reduce H. pylori infection rates.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • Helicobacter pylori (H. pylori) infection is a significant global health concern, particularly in children.
  • Understanding the prevalence, age of acquisition, and risk factors is crucial for developing effective prevention strategies.

Purpose of the Study:

  • To estimate the prevalence of H. pylori seropositivity in children aged 1-15 years.
  • To determine the age of acquisition for H. pylori infection.
  • To identify risk factors associated with H. pylori seroprevalence in this pediatric population.

Main Methods:

  • Serum samples from 1976 children were analyzed for H. pylori antibodies using ELISA.
  • Parental questionnaires collected data on household crowding, water sources, sanitation, and socioeconomic status (SES) using the Hollingshead Index.

Main Results:

  • H. pylori seropositivity was 53.5% in children aged 11-15 years.
  • Seroprevalence increased with higher crowding indices and was associated with middle and lower SES.
  • Multivariate analysis identified age (6-15 years), lower-middle SES, and paternal educational status as significant risk factors.

Conclusions:

  • H. pylori seropositivity in children is associated with increasing age, lower-middle socioeconomic status, and father's educational attainment.
  • Interventions focusing on improving sanitary conditions and enhancing educational status are recommended to reduce H. pylori seroprevalence.
Abstract

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