Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Goiter

Goiter

Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction to: The PanSurg-PREDICT Study: Endocrine Surgery During the COVID-19 Pandemic.

World journal of surgery·2021

Same author

The PanSurg-PREDICT Study: Endocrine Surgery During the COVID-19 Pandemic.

World journal of surgery·2021

Same author

The Global Task Force for Chronic Pain in People with HIV (PWH): Developing a research agenda in an emerging field.

AIDS care·2021

Same author

Radiological-pathological correlation of negative CT biopsy results enables high negative predictive value for thoracic malignancy.

Clinical radiology·2020

Same author

Modelling nasal airflow coefficients: an insight into the nature of airflow.

Rhinology·2020

Same author

Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL.

Gene therapy·2020

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

Multinodular goitre in lingual thyroid: case report.

M Zackaria¹, E J Chisholm, N S Tolley

¹Department of Otolaryngology, St Mary's Hospital, London, UK. drzackaria@hotmail.com

The Journal of Laryngology and Otology

|October 21, 2009

Summary

This summary is machine-generated.

A rare case of multinodular goitre in a lingual thyroid caused severe dysphagia in an elderly woman. This ectopic thyroid tissue presented with significant complications, highlighting the need for awareness of lingual thyroid abnormalities.

More Related Videos

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Related Experiment Videos

Last Updated: Jun 19, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Area of Science:

Endocrinology
Surgical Pathology

Background:

Lingual thyroid is a rare congenital anomaly, typically asymptomatic.
Ectopic thyroid tissue can undergo pathological changes.

Observation:

A 66-year-old woman presented with dysphagia and airway compromise.
Imaging revealed a multinodular goitre originating from a lingual thyroid.
The lingual goitre had undergone significant multinodular change.

Findings:

This is the first reported case of a lingual thyroid developing a multinodular goitre in later life.
Surgical excision via a midline, mandible-splitting approach was successfully performed.
The incidence of lingual thyroid is estimated between 1 in 3,000 to 10,000.

Implications:

This case expands the known clinical presentations of lingual thyroid.
Early recognition and management of symptomatic lingual goitres are crucial.
Further research into the long-term behavior of ectopic thyroid tissue is warranted.