Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gut-Brain Axis01:22

Gut-Brain Axis

The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic survey of biomarkers at early and mid-pregnancy identifies pregnancy-specialized immune regulation.

PLoS genetics·2026
Same author

Analytical Validation of an ELISA Assay for Maternal Autoantibody-Related Autism.

Diagnostics (Basel, Switzerland)·2026
Same author

Prenatal exposure to organophosphate ester flame retardants and plasticizers and maternal immune responses in three ECHO cohorts.

Environmental research·2026
Same author

Utilizing maternal autoantibody patterns to predict risk of autism and intellectual disability in offspring.

Research square·2026
Same author

Newborn IgG and IgM antibodies to maternal SARS-CoV-2 infection in pregnancy and child neurodevelopmental outcomes.

Brain, behavior, and immunity·2026
Same author

SARS-CoV-2 infection during pregnancy and neurodevelopmental outcomes in early childhood.

Translational psychiatry·2026

Related Experiment Video

Updated: Jun 19, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Breaking boundaries in neural-immune interactions.

A Kimberley McAllister1, Judy van de Water

  • 1Center for Neuroscience, One Shields Avenue, University of California, Davis, Davis, CA 95616, USA. kmcallister@ucdavis.edu

Neuron
|October 21, 2009
PubMed
Summary

The central nervous system (CNS) was long thought immune, but new evidence reveals constant communication between the nervous and immune systems. This finding challenges the traditional view of immune privilege in the CNS.

More Related Videos

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier
09:00

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Published on: April 5, 2017

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Jun 19, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
10:50

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier
09:00

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Published on: April 5, 2017

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice
08:49

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

Area of Science:

  • Neuroscience
  • Immunology
  • Neuroimmunology

Background:

  • The central nervous system (CNS) has historically been regarded as an immunologically privileged site, largely isolated from the peripheral immune system.
  • This concept of immune privilege suggested limited immune cell infiltration and inflammatory responses within the brain and spinal cord.

Discussion:

  • Emerging research across multiple scientific disciplines provides compelling evidence for a dynamic, bidirectional communication network linking the nervous and immune systems.
  • This interaction involves complex signaling pathways and cellular crosstalk, challenging the long-standing notion of CNS immune privilege.

Key Insights:

  • The CNS is not isolated but actively communicates with the immune system.
  • Bidirectional signaling pathways facilitate constant interaction between neural and immune components.
  • This interaction is crucial for maintaining homeostasis and responding to threats.

Outlook:

  • Future research should focus on elucidating the precise mechanisms of neuro-immune communication.
  • Understanding these pathways could lead to novel therapeutic strategies for neurological and autoimmune disorders.
  • Revisiting the concept of CNS immune privilege is essential for advancing neuroimmunology.