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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Nosocomial rotavirus gastroenteritis in Spain: a multicenter prospective study
M Victoria Gutiérrez-Gimeno1, Jose M Martin-Moreno, Javier Díez-Domingo
1Preventive Medicine and Public Health Department, College of Medicine and Dentistry, University of Valencia, Valencia, Spain.
The Pediatric Infectious Disease Journal
|October 21, 2009
Summary
Nosocomial rotavirus gastroenteritis in young children is a significant problem, with the G9P[8] strain being most common. Post-discharge surveillance identified additional cases, highlighting the burden of hospital-acquired rotavirus infections.
Area of Science:
- Pediatric Infectious Diseases
- Hospital Epidemiology
- Virology
Background:
- Nosocomial rotavirus gastroenteritis poses a substantial health burden in young children.
- Assessing the incidence of hospital-acquired rotavirus infections in children under two years old is crucial for public health.
Purpose of the Study:
- To determine the incidence of nosocomial rotavirus gastroenteritis in children younger than two years.
- To identify the predominant rotavirus genotypes causing hospital-acquired infections.
Main Methods:
- Prospective active surveillance for acute gastroenteritis (AGE) in pediatric hospital wards.
- Follow-up of children for 3 days post-discharge to capture all nosocomial cases.
- Stool specimen testing for rotavirus and genotyping.
Main Results:
- The accumulated incidence of nosocomial rotavirus disease was 2.8 cases per 100 inpatients.
- The most frequent genotype identified was G9P[8] (66% of cases).
- Post-discharge surveillance identified rotavirus gastroenteritis cases missed by standard inpatient monitoring.
Conclusions:
- Active surveillance reveals a significant burden of nosocomial rotavirus disease.
- G9P[8] is the predominant rotavirus genotype in hospital-acquired infections.
- Extended follow-up post-discharge is essential for accurate assessment of nosocomial rotavirus gastroenteritis.
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