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In-vitro Reconstitution of Bacterial Ubiquitination and VCP/p97-mediated Elimination
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NDP52: the missing link between ubiquitinated bacteria and autophagy

Stanimir Ivanov, Craig R Roy

    Nature Immunology
    |October 21, 2009
    PubMed
    Summary

    Mammalian cells tag invading bacteria with ubiquitin for destruction via autophagy. The protein NDP52 binds these ubiquitinated bacteria, aiding the formation of the autophagic membrane that engulfs them.

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