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Published on: June 27, 2018
Bacterial meningitis incidence in Thai children estimated by a rapid assessment tool (RAT)
Charung Muangchana1, Supamit Chunsuttiwat, Supachai Rerks-Ngarm
1Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand. charungm@hotmail
Insights
Bacterial meningitis affects young children, causing significant illness and death. This study estimates its incidence in Thai children under five, revealing higher rates than initially reported.
Area of Science:
- Pediatrics
- Infectious Diseases
- Epidemiology
Background:
- Acute bacterial meningitis is a major cause of child morbidity and mortality.
- Accurate incidence data is crucial for public health interventions.
Purpose of the Study:
- To estimate the incidence of bacterial meningitis in Thai children under five years.
- To determine the common bacterial pathogens responsible for meningitis in this age group.
Main Methods:
- Retrospective data collection of suspected meningitis cases using a rapid assessment tool (RAT).
- Analysis of clinical and laboratory data from 5 catchment areas over one year.
- Calculation of adjusted incidences considering laboratory quality and lumbar puncture rates.
Main Results:
- An unadjusted incidence of 24.6 per 100,000 children under five was observed.
- Confirmed bacterial meningitis accounted for 33.8% of suspected cases.
- Haemophilus influenzae type B was the most common pathogen (39.1%), followed by gram-positive cocci (26.1%).
- Adjusted incidence was approximately double the unadjusted rate.
Conclusions:
- The study provides an incidence range for bacterial meningitis in Thai children under five.
- Adjusted data suggests a higher burden of bacterial meningitis than initially estimated.
- Findings highlight the need for continued surveillance and prevention strategies.
Abstract:
Acute bacterial meningitis is an important cause of morbidity and mortality in children. To estimate the incidence of meningitis caused by all types of bacteria in Thai children under five years of age, data were collected using a rapid assessment tool (RAT) and analyzed. Clinical and laboratory data from suspected meningitis cases for a one-year period were retrospectively collected from 5 selected catchment areas located in the 4 regions of the country. Adjusted incidences of confirmed bacterial meningitis were calculated based on laboratory quality and lumbar puncture rates. Seventy-five suspected meningitis cases were identified among 305,023 children under age five in the catchment areas, with an unadjusted incidence of 24.6 per 100,000. Of these, 66.2, 55.9, and 33.8% were unconfirmed bacterial, purulent, and confirmed bacterial meningitis cases, respectively. Among the confirmed bacterial meningitis cases, 39.1, 26.1, 21.7 and 13.0% were caused by Haemophilus influenzae type B, gram-positive cocci, gram-negative bacilli, and Neisseria meningitidis, respectively. After adjusting based on the RAT application, the incidence of confirmed bacterial meningitis was about double that of the unadjusted incidence. This study gives an interval of possible incidences of bacterial meningitis in children under age five, which is between the unadjusted (low estimate) and adjusted (high estimate) incidences.
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