Related Experiment Videos

Cardiovascular risk factors in elderly normolipidemic acute myocardial infarct patients--a case controlled study from

Arun Kumar1, Suryakant Nagtilak, Ramiah Sivakanesan

  • 1Department of Biochemistry Manipal College of Medical Sciences, Pokhara, Nepal. arun732003@gmail.com

The Southeast Asian Journal of Tropical Medicine and Public Health
|October 22, 2009
PubMed

Insights

This study investigated risk factors in normolipidemic acute myocardial infarction (AMI) patients. Results show altered lipid profiles, increased oxidative stress, and elevated inflammatory markers in AMI patients compared to controls.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Research

Background:

  • Normolipidemic acute myocardial infarction (AMI) presents unique challenges in identifying risk factors.
  • Understanding the biochemical profile of AMI patients, even without hyperlipidemia, is crucial for targeted interventions.

Purpose of the Study:

  • To investigate various risk factors associated with normolipidemic AMI patients.
  • To compare serum lipid profiles, lipid peroxidation markers, antioxidants, and inflammatory markers between AMI patients and controls.

Main Methods:

  • Analyzed lipid profiles, lipid peroxidation markers (malondialdehyde, conjugated dienes), antioxidants (enzymatic and endogenous), and inflammatory markers (ceruloplasmin, CRP, fibrinogen) in 330 subjects.
  • Included 165 AMI patients admitted to the intensive coronary care unit (ICCU) and 165 age/sex-matched controls.
  • Assessed lipoprotein (a) and paraoxonase-1 activities.

Main Results:

  • AMI patients exhibited significantly higher total cholesterol and triglyceride levels, and lower high-density lipoprotein cholesterol (HDL-C).
  • Elevated levels of lipoprotein (a), ceruloplasmin, C-reactive protein (CRP), and fibrinogen were observed in AMI patients.
  • Lower activities of endogenous antioxidants (bilirubin, ascorbic acid, uric acid, albumin, superoxide dismutase, catalase, glutathione peroxidase, paraoxonase-1) and higher lipid peroxidation markers (malondialdehyde, conjugated dienes) were found in AMI patients.

Conclusions:

  • Normolipidemic AMI is associated with dyslipidemia, increased oxidative stress, and heightened inflammation.
  • These markers may serve as indicators for risk stratification and potential therapeutic targets in AMI patients.

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...