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Related Concept Videos

Eccentric Loading01:16

Eccentric Loading

922
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
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General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

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Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
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Design of Columns under an Eccentric Load01:21

Design of Columns under an Eccentric Load

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Designing columns to withstand eccentric loads is a critical aspect of structural engineering, ensuring structures can support off-center loads without failure. This design process must account for the additional normal stresses introduced by eccentric loading, which can significantly influence a column's stress distribution and overall stability. An eccentric load applied to a column induces normal stresses that can be conceptualized as a combination of stresses due to an equivalent...
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The Central Dogma01:25

The Central Dogma

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Overview
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Eccentric Axial Loading in a Plane of Symmetry01:16

Eccentric Axial Loading in a Plane of Symmetry

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Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.
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Measures of Central Tendency02:16

Measures of Central Tendency

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The "center" of a data set is also a way of describing location. The two most widely used measures of the "center" of the data are the mean (average) and the median. The words "mean" and "average" are often used interchangeably. The substitution of one word for the other is common practice. The technical term is "arithmetic mean" and "average" is technically a center location. However, in practice among non-statisticians,...
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Related Experiment Video

Updated: Jan 22, 2026

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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Liver masses with central or eccentric scar.

Tonsok Kim1, Masatoshi Hori, Hiromitsu Onishi

  • 1Department of Radiology, Osaka University, Graduate School of Medicine, Osaka, Japan. kim@radiol.med.osaka-u.ac.jp

Seminars in Ultrasound, CT, and MR
|October 22, 2009
PubMed
Summary

Differentiating focal nodular hyperplasia (FNH) from other liver tumors with central scars is crucial for treatment. Advanced imaging techniques, particularly liver-specific MRI contrast agents, enhance diagnostic accuracy.

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Area of Science:

  • Hepatobiliary imaging
  • Radiology
  • Oncology

Background:

  • A central or eccentric scar is a feature observed in various liver lesions, including focal nodular hyperplasia (FNH), hemangiomas, and hepatocellular carcinomas.
  • Distinguishing FNH from other solid hepatic tumors presenting with a central scar is clinically significant due to FNH often not requiring intervention.

Purpose of the Study:

  • To highlight the importance of differentiating FNH from other liver tumors with central scars.
  • To discuss the role of advanced imaging in the differential diagnosis of these lesions.

Main Methods:

  • Review of imaging characteristics of liver tumors with central or eccentric scars.
  • Discussion of the utility of multiphasic computed tomography (CT) and magnetic resonance imaging (MRI).

Main Results:

  • Central or eccentric scars are most commonly associated with FNH, large hemangiomas, and fibrolamellar hepatocellular carcinoma.
  • While rare, central scars can also be seen in conventional hepatocellular carcinoma, peripheral cholangiocarcinoma, and hepatic metastases.
  • Multiphasic CT and MRI are valuable tools for differential diagnosis.

Conclusions:

  • Accurate differentiation of FNH from other hepatic tumors with central scars is essential for appropriate patient management.
  • Liver-specific MRI contrast agents are expected to further improve the ability to distinguish FNH from other solid liver tumors.