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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 19, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

A comparison of two sets of microarray experiments to define allergic asthma expression pattern.

Annie Chamberland1, Anne-Marie Madore, Karine Tremblay

  • 1Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Chicoutimi, Quebec, Canada.

Experimental Lung Research
|October 22, 2009
PubMed
Summary

Microarray analysis of bronchial biopsies confirms its validity for identifying allergic asthma biomarkers. Earlier gene expression patterns remain relevant for discovering new allergic asthma pathways and therapeutic targets.

Related Experiment Videos

Last Updated: Jun 19, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • * Pulmonary Medicine
  • * Molecular Biology
  • * Immunology

Background:

  • * Allergic asthma is a complex respiratory disease with numerous contributing factors.
  • * Identifying reliable biomarkers is crucial for understanding and treating allergic asthma.
  • * Microarray technology offers a powerful tool for analyzing gene expression patterns.

Purpose of the Study:

  • * To validate the utility of microarrays in defining the gene expression profile of allergic asthma.
  • * To assess the consistency and relevance of gene expression data from microarrays conducted at different times.

Main Methods:

  • * Comparison of transcript expression from bronchial biopsies of allergic asthmatic and non-allergic healthy subjects.
  • * Analysis of two distinct microarray experiments (U95Av2 and U133A GeneChips) conducted two years apart.
  • * Statistical analysis to identify differentially expressed genes and overlapping findings between experiments.

Main Results:

  • * Microarrays identified 89 (U95Av2) and 40 (U133A) differentially expressed genes.
  • * 55% of genes identified by the U133A GeneChip were also found using the U95Av2 arrays.
  • * Immune signaling molecules and proteolytic enzymes were consistently identified as key categories in both experiments.

Conclusions:

  • * Microarray analysis of bronchial tissues is a relevant and valid approach for studying allergic asthma.
  • * Gene expression data from earlier microarray studies remain valuable for identifying novel biomarkers and pathways.
  • * Microarrays are a key technology for discovering new therapeutic targets in allergic asthma.