Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease II: Emphysema01:23

Chronic Obstructive Pulmonary Disease II: Emphysema

Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dimeric architecture and membrane thinning govern substrate recognition by human signal peptide peptidase.

Research square·2026
Same author

Generation of a recipient line for Rubisco engineering by multiplex genome editing in tobacco.

The Plant journal : for cell and molecular biology·2026
Same author

Early Effects of Poly(I:C)-induced Neuroinflammation on Hippocampal Astrocyte Function and Glycolytic Metabolism.

Journal of neurochemistry·2026
Same author

Feline leukocyte immunophenotyping: an optimised whole-blood flow cytometry protocol.

MethodsX·2026
Same author

Artificial Intelligence Enhanced Analysis of Coronary CT Angiography to Facilitate Chronic Total Occlusion Percutaneous Coronary Intervention.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2025
Same author

Organization of the yeast Seipin complex reveals differential recruitment of regulatory proteins.

Molecular biology of the cell·2025

Related Experiment Video

Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Pulmonary lobar interstitial emphysema.

Carlos Alberto Gonçalves1, Valdemar Martins, António Ochoa

  • 1Service of Neonatalogy, Hospital of the University of Coimbra and Institute of Histology and Embryology, Faculty of Medicine, Coimbra, Portugal. carloscond55@hotmail.com

Fetal and Pediatric Pathology
|October 22, 2009
PubMed
Summary

Pulmonary interstitial emphysema (PIE) is often seen in neonatal intensive care units, particularly in premature infants. This case highlights a rare localized PIE misdiagnosed as cystic adenomatoid malformation.

More Related Videos

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Related Experiment Videos

Last Updated: Jun 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

Area of Science:

  • Neonatology
  • Pulmonary Medicine
  • Pediatric Surgery

Background:

  • Pulmonary interstitial emphysema (PIE) is a known complication in neonates, especially those requiring positive pressure ventilation.
  • It presents as air within the lung's interstitial tissue, diagnosed via radiology.
  • PIE can be diffuse or localized, with the localized form being rarer.

Observation:

  • A case report of a premature male twin (33 weeks gestation) presenting with respiratory distress and pneumothoraces after birth.
  • Radiological imaging revealed diffuse cystic changes in the right upper lobe.
  • The infant underwent surgery with a preoperative diagnosis of congenital cystic adenomatoid malformation.

Findings:

  • Histological examination of the resected lobe definitively diagnosed localized pulmonary interstitial emphysema.
  • This finding contrasts with the initial clinical and radiological diagnosis.
  • Microscopic analysis included both light and scanning electron microscopy.

Implications:

  • This case underscores the importance of histological confirmation in diagnosing rare pulmonary conditions in neonates.
  • It highlights the potential for misdiagnosis of localized PIE as other cystic lung diseases.
  • Accurate diagnosis is crucial for appropriate management and understanding of neonatal respiratory complications.