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Calcium supplementation: effect on iron absorption.

J D Cook1, S A Dassenko, P Whittaker

  • 1Department of Medicine, Kansas University Medical Center, Kansas City 66103.

The American Journal of Clinical Nutrition
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Calcium supplements can hinder iron absorption, especially when taken with meals. This effect is more pronounced with calcium citrate and phosphate, potentially impacting women's daily iron intake.

Area of Science:

  • Nutrition Science
  • Human Physiology
  • Mineral Metabolism

Background:

  • Iron deficiency is a prevalent global health concern, particularly among women.
  • Calcium supplements are widely used for bone health.
  • Interactions between mineral absorption can affect nutritional status.

Purpose of the Study:

  • To investigate the impact of different calcium supplements on the absorption of both dietary nonheme iron and iron supplements.
  • To determine if the presence of food influences the inhibitory effect of calcium on iron absorption.

Main Methods:

  • A double-radioisotope technique was employed to quantify iron absorption.
  • Sixty-one healthy volunteers participated in the study.
  • Absorption was measured with and without food, using various calcium supplements (carbonate, citrate, phosphate) and iron sources (ferrous sulfate, dietary nonheme iron).

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Main Results:

  • Calcium carbonate did not inhibit iron absorption when taken without food.
  • Calcium citrate and calcium phosphate significantly reduced iron absorption by 49% and 62%, respectively, when taken without food at higher doses.
  • All tested calcium supplements inhibited iron absorption from both supplements and dietary sources when consumed with meals.
  • The inhibitory effect was more pronounced with meals high in calcium and low in iron.

Conclusions:

  • Taking calcium supplements with meals can significantly impair iron absorption.
  • Calcium citrate and calcium phosphate exhibit a stronger inhibitory effect on iron absorption compared to calcium carbonate.
  • These findings suggest that regular calcium supplementation with meals may pose a challenge for women to meet their daily iron requirements.