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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Published on: March 20, 2015

Patterned silver nanorod array substrates for surface-enhanced Raman scattering.

Nicole E Marotta¹, Jabulani R Barber, Peter R Dluhy

¹School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.

Applied Spectroscopy

|October 22, 2009

Summary

This summary is machine-generated.

A new method allows for the simultaneous batch fabrication of multiple surface-enhanced Raman scattering (SERS) substrates. This technique ensures high uniformity and minimizes contamination for reliable SERS analysis.

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Area of Science:

Materials Science
Nanotechnology
Analytical Chemistry

Background:

Surface-enhanced Raman scattering (SERS) requires specialized substrates for optimal signal amplification.
Current fabrication methods can be time-consuming and lack batch processing capabilities.

Purpose of the Study:

To develop a novel, efficient method for batch fabrication of SERS substrates.
To evaluate the uniformity and SERS performance of substrates produced by the new method.

Main Methods:

Utilized glancing angle deposition in an electron beam evaporator to create silver nanorod arrays on multiple slides simultaneously.
Employed contact printing of a polymer followed by photochemical curing to create patterned wells on the nanorod arrays.

Main Results:

Achieved simultaneous fabrication of six SERS substrates with high structural uniformity.
Demonstrated physical isolation of nanorod arrays, reducing cross-contamination.
Confirmed compatibility with existing SERS microscopy and suitability for small fluid volumes.

Conclusions:

The developed method offers a scalable and robust approach for producing high-performance SERS substrates.
The technique addresses key limitations in current SERS substrate fabrication, enabling more efficient and reliable analyses.
Further examination of variability confirmed the method's consistency for practical applications.