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Related Experiment Videos

Vitamin E (tocopherols) in human cerebrospinal fluid.

G T Vatassery1, M J Nelson, G J Maletta

  • 1Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Minneapolis, MN 55417.

The American Journal of Clinical Nutrition
|January 1, 1991
PubMed
Summary

Vitamin E (tocopherols) levels in cerebrospinal fluid (CSF) correlate with protein concentrations, indicating a link in transport. Human CSF also contains antioxidants that protect vitamin E from oxidation.

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Area of Science:

  • Neurochemistry
  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin E (tocopherols) are crucial lipid-soluble antioxidants.
  • Understanding vitamin E transport and presence in cerebrospinal fluid (CSF) is important for neurological health.
  • Previous research has not fully elucidated the relationship between vitamin E levels and protein concentrations in human CSF.

Purpose of the Study:

  • To quantify alpha- and gamma-tocopherol concentrations in human CSF and serum.
  • To investigate the correlation between vitamin E levels in CSF and CSF protein/albumin concentrations.
  • To assess the antioxidant capacity of human CSF against free-radical-induced oxidation.

Main Methods:

  • Cerebrospinal fluid (CSF) and blood samples were collected from 40 healthy adult males during myelography.

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  • Vitamin E (tocopherol) concentrations were measured using liquid chromatography.
  • In vitro oxidation assays were performed on CSF using a free-radical generator.

    • Main Results:

    • Normal alpha- and gamma-tocopherol concentrations in CSF were determined for subjects with normal CSF protein.
    • Significant positive correlations were found between CSF alpha-tocopherol and both total protein and albumin concentrations (P < 0.001).
    • Human CSF demonstrated a measurable lag period during in vitro oxidation, indicating the presence of other antioxidants.

    Conclusions:

    • Tocopherol transport into the CSF appears to be associated with plasma protein transport mechanisms.
    • Human CSF possesses intrinsic antioxidant properties that can protect vitamin E from oxidative damage.