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Relationship between high-sensitivity C-reactive protein and clinical functional outcome after acute ischemic stroke

In-Uk Song1, Joong-Seok Kim, Yeong-In Kim

  • 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Cerebrovascular Diseases (Basel, Switzerland)
|October 22, 2009
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) measured on the seventh hospital day, not admission, predicts functional disability after ischemic stroke. Elevated hs-CRP levels indicate a poorer prognosis in Korean patients.

Area of Science:

  • Neurology
  • Biomarkers
  • Cardiovascular Research

Background:

  • High-sensitivity C-reactive protein (hs-CRP) is a known predictor of coronary ischemic events.
  • Prognosis of functional disability post-cerebrovascular disease is not well-established.
  • This study investigates hs-CRP's prognostic significance in acute ischemic stroke patients with functional disability.

Purpose of the Study:

  • To determine the prognostic value of hs-CRP levels for functional disability after acute ischemic stroke.
  • To assess the correlation between hs-CRP levels and long-term functional outcomes.
  • To evaluate the timing of hs-CRP measurement for optimal prognostic prediction.

Main Methods:

  • Analyzed 417 Korean patients with ischemic stroke within 24 hours of symptom onset.
  • Measured hs-CRP levels on admission and the seventh hospital day.
  • Correlated hs-CRP concentrations with modified Rankin Scale (mRS) scores at 12 months post-stroke.

Main Results:

  • hs-CRP levels on admission and day seven significantly correlated with 12-month mRS scores.
  • mRS scores showed a stronger association with hs-CRP levels on the seventh hospital day compared to admission levels.
  • Elevated hs-CRP on day seven was a significant predictor of functional disability.

Conclusions:

  • Elevated hs-CRP on the seventh hospital day strongly predicts functional disability prognosis after ischemic stroke.
  • hs-CRP is a valuable prognostic marker for ischemic stroke, particularly in the Korean population.
  • Timing of hs-CRP measurement is crucial for predicting stroke outcomes.
Abstract

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