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Related Experiment Video

Updated: Jun 19, 2026

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

Recurrent endogenous Candida.

Sengul Ozdek¹, Berrak Urgancioglu, Sertac Ozturk

¹Gazi University, School of Medicine, Ankara, Turkey.

Annals of Ophthalmology (Skokie, Ill.)

|October 23, 2009

Summary

A 61-year-old developed Candida infection in the blood after pancreatic surgery, leading to eye inflammation. Treatment with fluconazole and surgery improved vision, but inflammation returned with chemotherapy and resolved upon its cessation.

Area of Science:

Ophthalmology
Infectious Diseases
Oncology

Background:

Post-surgical candidemia can present with ocular manifestations.
Pancreatic cancer patients undergoing surgery are at risk for opportunistic infections.

Observation:

A 61-year-old patient developed bilateral multifocal chorioretinitis and vitritis following pancreatic tumor surgery.
Ocular lesions initially responded to fluconazole therapy.
Pars plana vitrectomy improved visual acuity, but vitritis recurred during chemotherapy.

Findings:

Recurrent vitritis during chemotherapy resolved spontaneously upon treatment cessation.
This suggests a potential link between chemotherapy and ocular inflammation in candidemia patients.

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Implications:

Ocular candidiasis should be considered in immunocompromised patients with unexplained vision loss.
Management requires a multidisciplinary approach involving infectious disease, oncology, and ophthalmology specialists.
Further research is needed to understand the interplay between chemotherapy, candidemia, and ocular inflammation.