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Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic

S Takahagi1, S Mihara, K Iwamoto

  • 1Department of Dermatology, Hiroshima University, Japan.

Allergy
|October 23, 2009
PubMed

Insights

Markers of blood coagulation and fibrinolysis, including fibrin degradation products (FDP) and d-dimer, alongside C-reactive protein (CRP), may help assess chronic urticaria (CU) activity. These markers correlate with disease severity and treatment response in CU patients.

Area of Science:

  • Dermatology
  • Hematology
  • Immunology

Background:

  • Chronic urticaria (CU) management requires accurate assessment of disease severity and activity.
  • Currently, reliable biomarkers for evaluating CU severity and activity are lacking.
  • Elevated blood coagulation and fibrinolysis markers have been observed in severe CU cases.

Purpose of the Study:

  • To investigate coagulation/fibrinolysis markers and inflammation markers in CU patients.
  • To determine the relationship between these markers and CU disease activity.
  • To explore the utility of these markers in assessing CU severity.

Main Methods:

  • Plasma fibrin degradation products (FDP), d-dimer, and serum C-reactive protein (CRP) were measured.
  • Evaluations included disease severity and skin reactions to autologous serum.
  • 82 CU patients and 37 patients with acute urticaria, idiopathic angioedema (AE), or inducible urticaria (IU) were studied.

Main Results:

  • FDP levels were significantly higher in CU patients compared to IU patients.
  • No significant differences in FDP, d-dimer, or CRP were found among different urticaria types.
  • These markers correlated with each other and were associated with CU disease severity, but not autologous serum skin reactions.

Conclusions:

  • Plasma FDP, d-dimer, and serum CRP measurements show potential for assessing CU disease activity.
  • Changes in these marker levels correlated with improvements or worsening of CU.
  • These biomarkers may aid in monitoring treatment response and disease progression in CU.
Abstract

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