Related Experiment Video
Updated: Jun 19, 2026

Microscopic Replantation of Penile Glans Amputation Due to Circumcision
Published on: June 3, 2022
To circumcise or not to circumcise? Circumcision in patients with bleeding disorders
V Rodriguez1, R Titapiwatanakun, C Moir
1Division of Pediatric Hematology and Oncology, Mayo Clinic, Rochester, MN 55905, USA. rodriguez.vilmarie@mayo.edu
Circumcision in patients with bleeding disorders presents a notable risk of complications, with an overall bleeding incidence of 23%. Even with factor replacement, significant bleeding can occur, necessitating informed consent regarding potential risks.
Area of Science:
- Pediatric Surgery
- Hematology
- Genetics
Background:
- Circumcision is a common procedure in male neonates.
- Limited data exists on circumcision outcomes in patients with bleeding disorders.
Purpose of the Study:
- To analyze circumcision outcomes in children with bleeding disorders.
- To determine complication extent and provide management guidelines.
Main Methods:
- Retrospective review of medical records from 2000-2007.
- Identified 55 children and young adults who underwent circumcision.
- Documented complications and management strategies.
Main Results:
- 48 patients underwent circumcision; 21 had known bleeding disorders, 27 diagnosed later.
- Overall bleeding complication incidence was 23% (11/48).
- Significant bleeding occurred despite adequate factor replacement in some cases.
Conclusions:
- Circumcision in patients with bleeding disorders has a comparable bleeding risk to the general population.
- Informed consent is crucial, highlighting potential bleeding risks even with factor replacement.
- Guidelines for managing circumcision in this population are needed.
Related Concept Videos
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Epistaxis
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Pre-Procedural Guidelines for Assessing Blood Pressure