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Updated: Jun 19, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
Published on: March 10, 2021
The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related
M Wurm1, S Tischer, S Immenschuh
1Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.
Abstract:
This article describes the identification of the novel human leukocyte antigen (HLA) allele DRB1*07 7 that was detected in a potential stem-cell donor of Caucasian origin. Compared to DRB1*070101, the new allele is characterized by a nonsynonymous nucleotide exchange of C-->T at position 201 in exon 2 replacing Arg by Trp in codon 72. As this sequence variation has not been seen earlier in any other HLA-DRB allele, it is most probably the result of a point mutation.
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