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Related Concept Videos

CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
CRISPR and crRNAs02:53

CRISPR and crRNAs

Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
The Antiviral System of Bacteria and Archaea: CRISPR01:23

The Antiviral System of Bacteria and Archaea: CRISPR

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this defense.

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Related Experiment Video

Updated: Jun 19, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

CRISPI: a CRISPR interactive database.

Christine Rousseau1, Mathieu Gonnet, Marc Le Romancer

  • 1IRISA-INRIA, Campus de Beaulieu, 35042 Rennes cedex, France. croussea@irisa.fr; jnicolas@irisa.fr

Bioinformatics (Oxford, England)
|October 23, 2009
PubMed
Summary
This summary is machine-generated.

This study presents CRISPI, a comprehensive database of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and associated genes in archaea and bacteria. It offers a user-friendly interface for analyzing CRISPR sequences and related genetic elements.

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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

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Last Updated: Jun 19, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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Published on: April 25, 2022

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
10:08

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Published on: December 21, 2021

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are genetic elements found in prokaryotes.
  • Understanding CRISPR and associated genes (CAS) is crucial for microbial genomics.

Purpose of the Study:

  • To systematically identify and catalog all CRISPR occurrences in archaeal and bacterial genomes.
  • To develop a comprehensive database (CRISPI) of CRISPR and CAS genes.
  • To provide a user-friendly platform for accessing and analyzing CRISPR data.

Main Methods:

  • Development of a formal model for CRISPR identification.
  • Systematic analysis of all available Archaea and Bacteria genomes.
  • Creation of a relational database (CRISPI) integrating CRISPR and CAS gene information.

Main Results:

  • A comprehensive relational database, CRISPI, containing all identified CRISPR structures and associated CAS genes.
  • A web interface enabling users to query the database, analyze personal sequences, and calculate sequence similarity.

Conclusions:

  • CRISPR systems are widespread in archaea and bacteria.
  • The CRISPI database provides a valuable resource for researchers studying CRISPR biology and evolution.
  • The associated web interface facilitates efficient exploration and analysis of CRISPR-related genomic data.