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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Jun 19, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Immunophenotypic variations in mantle cell lymphoma.

Juehua Gao1, LoAnn Peterson, Beverly Nelson

  • 1Dept of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

American Journal of Clinical Pathology
|October 23, 2009
PubMed
Summary
This summary is machine-generated.

Mantle cell lymphoma (MCL) often shows unusual immunophenotypes, with variations in CD5, CD10, CD23, and FMC7 markers. Recognizing these variations is crucial for accurate B-cell lymphoma subclassification.

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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors
14:30

Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors

Published on: August 7, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors
14:30

Immunophenotyping and Cell Sorting of Human MKs from Human Primary Sources or Differentiated In Vitro from Hematopoietic Progenitors

Published on: August 7, 2021

Area of Science:

  • Hematology
  • Oncology
  • Immunophenotyping

Background:

  • Mantle cell lymphoma (MCL) is a B-cell neoplasm typically characterized by a specific immunophenotype.
  • Standard MCL immunophenotype includes pan-B-cell antigens, CD5+, CD10-, CD23-, and FMC7+.

Purpose of the Study:

  • To investigate the frequency and spectrum of variant immunophenotypes in a cohort of MCL patients.
  • To assess the correlation between immunophenotypic variations and proliferation index (Ki-67).

Main Methods:

  • Retrospective analysis of 52 patients with confirmed MCL diagnoses.
  • Immunohistochemical analysis for B-cell antigens (CD5, CD10, CD23, FMC7) and Ki-67.
  • Evaluation of variant immunophenotypes in classical and variant MCL subtypes.

Main Results:

  • Variant immunophenotypes were identified in 21 out of 52 (40%) MCL patients.
  • Specific variations included CD5- (12%), CD10+ (8%), CD23+ (21%), and FMC7- (11%).
  • No significant difference in Ki-67 proliferation index was observed between variant and typical MCL immunophenotypes, although high proliferation was noted in blastoid and pleomorphic variants.

Conclusions:

  • Immunophenotypic variations are common in Mantle Cell Lymphoma.
  • Accurate identification of these variations is essential for precise subclassification of B-cell lymphomas.
  • The study highlights the importance of comprehensive immunophenotypic analysis in MCL diagnosis.