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Acquired selective factor X deficiency in acute nonlymphocytic leukemia
M T Caimi1, R Redaelli, D Cattaneo
1Department of Haematology, Ospedale Niguarda Cà Granda, Milano, Italy.
American Journal of Hematology
|January 1, 1991
Summary
This case report details acute nonlymphocytic leukemia (ANLL) with a rare acquired Factor X (FX) deficiency. The deficiency persisted despite fresh frozen plasma treatment, with no identified neutralizing activity in the patient’s plasma.
Area of Science:
- Hematology
- Coagulation Disorders
Background:
- Acute nonlymphocytic leukemia (ANLL) is a heterogeneous group of myeloid neoplasms.
- Coagulation factor deficiencies can complicate the management of hematological malignancies.
Observation:
- A patient presented with acute nonlymphocytic leukemia (ANLL).
- Simultaneously, a selective acquired Factor X (FX) deficiency was identified at the time of diagnosis.
Findings:
- The acquired FX deficiency was refractory to treatment with fresh frozen plasma (FFP) infusion.
- In vitro studies revealed no neutralizing activity in the patient's plasma against Factor X.
Implications:
- This case highlights a rare association between ANLL and acquired FX deficiency.
- The unknown etiology of this specific FX deficiency warrants further investigation.
- Understanding such rare coagulation abnormalities is crucial for optimizing patient care in hematology.