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Clusterin overexpression and relapse-free survival in breast cancer
Cha Kyong Yom1, Hee-Yeon Woo, Sun Young Min
1Department of Surgery, Kangbuk Samsung Hospital, Jongro-Ku, Seoul 110-746, South Korea.
Background:
The prognostic significance of the antiapoptotic protein secretory clusterin overexpression in breast cancer is unclear.
Patients And Methods:
Secretory clusterin expression was explained in three hundred and fifty-two patients with breast cancer by immunohistochemistry. Clusterin overexpression was tested for correlation with overall survival (OS) and relapse-free survival (RFS).
Results:
The overall frequency of clusterin overexpression was 52% (178 out of 342) in breast cancer; 44% for in situ carcinomas and 53% for invasive cancer. Among fifty-six patients with tumor recurrence, clusterin overexpression was found in 74% (14 out of 19) in breast cancer
Conclusion:
Our results suggest that clusterin overexpression might be a predictive factor for recurrence in
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