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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
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Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

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Published on: March 3, 2023

Oral allergy syndrome.

Yasuto Kondo1, Atsuo Urisu

  • 1Department of Pediatrics, Fujita Health University, Aichi, Japan. ykondo@fujita-hu.ac.jp

Allergology International : Official Journal of the Japanese Society of Allergology
|October 23, 2009
PubMed
Summary

Oral allergy syndrome (OAS), also known as pollen-food syndrome (PFS), involves oral allergy symptoms triggered by cross-reactivity between pollen and certain foods. Treatment requires careful history taking due to variable antigen sensitivity and potential reactions to cooked foods.

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Area of Science:

  • Immunology
  • Allergology
  • Clinical Medicine

Background:

  • Oral allergy syndrome (OAS) is an IgE-mediated allergic reaction localized to the oral mucosa.
  • Pollen-food syndrome (PFS) is a common manifestation of OAS, involving sensitization to pollen with subsequent reactions to structurally similar food antigens.
  • Latex-fruit syndrome is another recognized condition presenting with OAS.

Purpose of the Study:

  • To define Oral Allergy Syndrome (OAS) and its relationship with Pollen-Food Syndrome (PFS).
  • To highlight key considerations in the diagnosis and management of OAS/PFS.
  • To discuss the role of antigen lability and immunotherapy in PFS.

Main Methods:

  • Literature review and synthesis of existing knowledge on OAS and PFS.
  • Analysis of clinical characteristics and diagnostic approaches for OAS/PFS.
  • Discussion of treatment strategies, including dietary modifications and immunotherapy.

Main Results:

  • OAS symptoms are localized to the oral mucosa and depend on antigen lability.
  • PFS involves cross-reactivity between airway-sensitizing pollens and food allergens (Class 2 food allergy).
  • Not all PFS symptoms are exclusively OAS; some individuals react to cooked antigens, necessitating thorough patient history.

Conclusions:

  • Effective management of OAS/PFS requires understanding antigen properties and patient-specific reactions.
  • Careful historical inquiry is crucial, especially regarding reactions to cooked foods and atopic dermatitis exacerbation.
  • Immunotherapy targeting cross-reactive pollens is a potential treatment avenue for PFS.