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Updated: Jun 19, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Transition metal-catalyzed C-H activation reactions: diastereoselectivity and enantioselectivity
Ramesh Giri1, Bing-Feng Shi, Keary M Engle
1Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, IL 61801, USA.
Abstract:
This critical review discusses historical and contemporary research in the field of transition metal-catalyzed carbon-hydrogen (C-H) bond activation through the lens of stereoselectivity. Research concerning both diastereoselectivity and enantioselectivity in C-H activation processes is examined, and the application of concepts in this area for the development of novel carbon-carbon and carbon-heteroatom bond-forming reactions is described. Throughout this review, an emphasis is placed on reactions that are (or may soon become) relevant in the realm of organic synthesis (221 references).
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