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Suicide in twins
A Roy1, N L Segal, B S Centerwall
1Hillside Hospital, New York, NY 11004.
Archives of General Psychiatry
|January 1, 1991
Summary
Genetic factors may influence suicide risk, as indicated by twin studies. Research suggests a predisposition to psychiatric disorders, which are linked to suicide, may be inherited.
Area of Science:
- Psychiatry
- Behavioral Genetics
- Epidemiology
Background:
- Suicide exhibits familial clustering, suggesting a potential genetic component.
- Twin studies are valuable for disentangling genetic and environmental influences on complex behaviors like suicide.
Observation:
- This study examined 176 twin pairs where at least one twin died by suicide.
- Concordance rates for suicide were higher in monozygotic (11.3%) than dizygotic (1.8%) twin pairs.
- A subsample revealed a high prevalence of psychiatric disorders among suicide victims and their surviving co-twins, as well as in their extended families.
Findings:
- The data indicate a significant genetic influence on suicide, primarily through a predisposition to associated psychiatric disorders.
- The findings suggest that inherited factors contributing to suicide may be largely mediated by genetic links to mental health conditions.
Implications:
- Understanding the genetic basis of psychiatric disorders linked to suicide is crucial for prevention strategies.
- Further research is needed to determine if an independent genetic component for suicide exists beyond its association with psychiatric illness.
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