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Related Experiment Videos

Suicide in twins.

A Roy1, N L Segal, B S Centerwall

  • 1Hillside Hospital, New York, NY 11004.

Archives of General Psychiatry
|January 1, 1991
PubMed
Summary

Genetic factors may influence suicide risk, as indicated by twin studies. Research suggests a predisposition to psychiatric disorders, which are linked to suicide, may be inherited.

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Area of Science:

  • Psychiatry
  • Behavioral Genetics
  • Epidemiology

Background:

  • Suicide exhibits familial clustering, suggesting a potential genetic component.
  • Twin studies are valuable for disentangling genetic and environmental influences on complex behaviors like suicide.

Observation:

  • This study examined 176 twin pairs where at least one twin died by suicide.
  • Concordance rates for suicide were higher in monozygotic (11.3%) than dizygotic (1.8%) twin pairs.
  • A subsample revealed a high prevalence of psychiatric disorders among suicide victims and their surviving co-twins, as well as in their extended families.

Findings:

  • The data indicate a significant genetic influence on suicide, primarily through a predisposition to associated psychiatric disorders.
  • The findings suggest that inherited factors contributing to suicide may be largely mediated by genetic links to mental health conditions.

Implications:

  • Understanding the genetic basis of psychiatric disorders linked to suicide is crucial for prevention strategies.
  • Further research is needed to determine if an independent genetic component for suicide exists beyond its association with psychiatric illness.

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