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Updated: Jun 19, 2026

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Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Purple glove syndrome - a case report].
I C Warnecke1, U Raute-Kreinsen, S Schirmer
1Klinikum Bielefeld Mitte, Klinik für Plastische, Rekonstruktive und Asthetische Chirurgie, Handchirurgie, Bielefeld.
Summary
Purple glove syndrome (PGS) is a soft tissue injury from phenytoin, causing discoloration and pain. Prompt medical intervention, including potential surgery for severe cases, is crucial for recovery.
Area of Science:
- Pharmacology
- Dermatology
- Surgical Complications
Background:
- Purple glove syndrome (PGS) is a rare but serious soft tissue injury.
- It occurs following intravenous phenytoin administration or oral overdose.
- Incidence rates range from 0-6%.
Observation:
- Typical symptoms include purple discoloration, edema, pain, and reduced range of motion.
- Severe cases can progress to abscess, skin loss, and compartment syndrome.
- A case report details a 40-year-old female patient with severe PGS.
Findings:
- The patient presented 4 days after intravenous phenytoin administration.
- She underwent successful surgical revision for severe complications.
- Early recognition and intervention are key to managing PGS.
Implications:
- This case highlights the importance of vigilant monitoring for PGS after phenytoin administration.
- Prompt surgical intervention may be necessary for severe complications.
- Understanding PGS management is vital for clinicians managing patients on phenytoin therapy.
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