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[Inflammaging. Aging inflammatory origin]
Ana Patricia Navarrete-Reyes1, Mariano Montaña-Alvarez
1Clinica de Geriatría del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. ap_navarrete09@hotmail.com
Summary
As people live longer, chronic inflammation, or inflammaging, increases, potentially driving age-related diseases. Healthy centenarians show this inflammation is balanced by anti-inflammatory responses.
Area of Science:
- Immunology
- Gerontology
- Molecular Biology
Context:
- Increased human life expectancy is linked to immune system changes.
- Prolonged exposure to antigens activates the innate immune system, causing chronic low-grade inflammation (inflammaging).
- This inflammatory state is associated with aging and the pathogenesis of chronic diseases like Alzheimer's, diabetes, and cardiovascular conditions.
Purpose:
- To explore the role of inflammaging in aging and chronic diseases.
- To investigate the cellular mechanisms underlying inflammaging, including the involvement of nuclear factor kappa B, sirtuins, forkhead box O, and KLOTHO.
- To examine the relationship between chronic inflammation and the development of age-related degenerative diseases.
Summary:
- Inflammaging, a chronic inflammatory state associated with aging, involves the activation of cellular systems regulating gene expression and cellular defense mechanisms.
- These systems are implicated in oxidative stress resistance, apoptosis, and DNA repair, and their activation is linked to diseases such as Alzheimer's, diabetes, and cardiovascular disease.
- A key question remains whether inflammaging causes these diseases or vice versa, though healthy centenarians exhibit a balanced inflammatory state.
Impact:
- Understanding inflammaging is crucial for addressing age-related chronic and degenerative diseases.
- Identifying the balance between pro- and anti-inflammatory molecules in centenarians offers insights into healthy aging.
- This research may pave the way for novel therapeutic strategies targeting inflammation to improve healthspan and combat age-related pathologies.
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