Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation01:38

Inflammation

Overview
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty and Cancer Prognosis.

Current oncology reports·2024
Same author

Sarcopenia in older patients with diffuse large B-cell lymphoma and its association with response to treatment: A cohort study.

Journal of geriatric oncology·2023
Same author

Factors Associated with Nonattendance to a Geriatric Clinic among Mexican Older Adults.

Gerontology·2021
Same author

Staying in a Burning House: Perks and Perils of a Hotline in the Times of COVID-19.

Journal of the American Geriatrics Society·2020
Same author

A pilot study of an accelerometer-equipped smartphone to monitor older adults with cancer receiving chemotherapy in Mexico.

Journal of geriatric oncology·2017
Same author

Global geriatric oncology: Achievements and challenges.

Journal of geriatric oncology·2017

Related Experiment Videos

[Inflammaging. Aging inflammatory origin].

Ana Patricia Navarrete-Reyes1, Mariano Montaña-Alvarez

  • 1Clinica de Geriatría del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. ap_navarrete09@hotmail.com

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|October 24, 2009
PubMed
Summary

As people live longer, chronic inflammation, or inflammaging, increases, potentially driving age-related diseases. Healthy centenarians show this inflammation is balanced by anti-inflammatory responses.

Related Experiment Videos

Area of Science:

  • Immunology
  • Gerontology
  • Molecular Biology

Context:

  • Increased human life expectancy is linked to immune system changes.
  • Prolonged exposure to antigens activates the innate immune system, causing chronic low-grade inflammation (inflammaging).
  • This inflammatory state is associated with aging and the pathogenesis of chronic diseases like Alzheimer's, diabetes, and cardiovascular conditions.

Purpose:

  • To explore the role of inflammaging in aging and chronic diseases.
  • To investigate the cellular mechanisms underlying inflammaging, including the involvement of nuclear factor kappa B, sirtuins, forkhead box O, and KLOTHO.
  • To examine the relationship between chronic inflammation and the development of age-related degenerative diseases.

Summary:

  • Inflammaging, a chronic inflammatory state associated with aging, involves the activation of cellular systems regulating gene expression and cellular defense mechanisms.
  • These systems are implicated in oxidative stress resistance, apoptosis, and DNA repair, and their activation is linked to diseases such as Alzheimer's, diabetes, and cardiovascular disease.
  • A key question remains whether inflammaging causes these diseases or vice versa, though healthy centenarians exhibit a balanced inflammatory state.

Impact:

  • Understanding inflammaging is crucial for addressing age-related chronic and degenerative diseases.
  • Identifying the balance between pro- and anti-inflammatory molecules in centenarians offers insights into healthy aging.
  • This research may pave the way for novel therapeutic strategies targeting inflammation to improve healthspan and combat age-related pathologies.