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Updated: Jun 19, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Synthesis of conformationally constrained diaminodicarboxylic acid derivatives
Robin A Weatherhead1, Michael D Carducci, Eugene A Mash
1Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, USA.
Abstract:
Functionally protected forms of three conformationally constrained diaminodicarboxylic acids were synthesized and characterized. 2,2'-Diaminospiro[3.3]heptane-2,2'-dicarboxylic acid, an analogue of diaminopimelic acid, was prepared in racemic form and the structure established by X-ray crystallographic analysis of the methyl ester hydrochloride. trans-1,4-Diaminocyclohexane-1,4-dicarboxylic acid was prepared and its structure established by X-ray crystallographic analysis of the corresponding Cbz-protected ethyl ester. cis- and trans-2,6-diamino-1,2,3,5,6,7-hexahydro-s-indacene-2,6-dicarboxylic acids were synthesized and the structures assigned by X-ray crystallographic analysis of the corresponding Boc-protected ethyl ester and Cbz-protected ethyl ester, respectively.
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