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c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13)
T Y Wang1, D M Samples, R Dabdoub
1Department of Molecular Oncology, Alton Ochsner Medical Foundation, New Orleans, LA 70121.
Cancer Genetics and Cytogenetics
|January 1, 1991
Abstract:
Molecular and cytogenetic analyses were performed on chronic B-lymphocytic cell leukemia (CLL) from a 57-year-old male patient with del(12)(p13) anomaly. The deletion did not remove the K-ras-2 gene. However, c-myc gene amplification correlated with high-level expression, suggesting the involvement of this gene in the induction of neoplasia in this patient.