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11:27
A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Drug release from lipid liquid crystalline phases: relation with phase behavior
Fátima O Costa-Balogh1, Emma Sparr, João José Simões Sousa
1Centro de Estudos Farmacêuticos, Laboratório de Galénica e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra, Coimbra, Portugal. fatima.costa@infarmed.pt
Drug Development and Industrial Pharmacy
|October 24, 2009
Summary
Monoolein and phytantriol systems show potential for sustained propranolol hydrochloride (PHCl) release. Release rates were primarily first-order, influenced by phase changes during dissolution.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Physical Chemistry
Background:
- Investigated the release of propranolol hydrochloride (PHCl), a water-soluble amphiphilic drug.
- Utilized monoolein (MO)/water and phytantriol/water systems for drug delivery.
Purpose of the Study:
- To evaluate the potential of MO and phytantriol systems for sustained drug release.
- To correlate drug dissolution profiles with the phase behavior and viscosity of liquid crystalline phases.
Main Methods:
- Studied drug release kinetics from MO/water and phytantriol/water systems.
- Analyzed phase behavior and viscosity of liquid crystalline phases.
- Incorporated diolein to stabilize cubic phases and prevent lamellar phase formation.
Main Results:
- Formulations exhibited first-order release rates with a diffusion-controlled mechanism.
- Certain formulations, particularly those with MO, approached zero-order release within the initial 120 minutes.
- Phase changes during dissolution were observed to influence the release mechanism.
Conclusions:
- Both monoolein and phytantriol demonstrate significant potential for developing sustained-release formulations of propranolol hydrochloride.
- The drug release mechanism is sensitive to alterations in the system's phase behavior during dissolution.
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