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Thrombotic events after pediatric liver transplantation

Chee Yee Ooi1, Leonardo R Brandão, Lauren Zolpys

  • 1SickKids Transplant Centre, Toronto, ON, Canada.

Pediatric Transplantation
|October 24, 2009
PubMed

Insights

Early thrombosis (TE) affects 16% of pediatric liver transplant (LT) recipients. Deep vein thrombosis (DVT) occurred in 8%, highlighting the need for further research into prevention strategies.

Area of Science:

  • Pediatric Hepatology
  • Transplant Surgery
  • Vascular Medicine

Background:

  • Thrombotic events (TE) pose a significant risk for morbidity and mortality in pediatric liver transplant (LT) recipients.
  • Understanding the incidence and characteristics of early TE is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the incidence of early TE within the first month post-pediatric LT.
  • To compare the characteristics of pediatric LT recipients with and without TE.

Main Methods:

  • Retrospective review of 88 pediatric LT cases from January 2002 to October 2007.
  • Doppler confirmation of deep vein thrombosis (DVT) and arterial thromboembolism (ATE) within the first month post-transplant.

Main Results:

  • Overall incidence of early TE was 16% (14/88 patients).
  • DVT occurred in 8% (7/88) and ATE in 8% (7/88) of patients.
  • Six patients (6.8%) developed symptomatic central venous line-related DVT.

Conclusions:

  • The incidence of early TE post-pediatric LT is substantial (16%), with DVT accounting for half of these events.
  • No significant differences in baseline characteristics were found between patients with and without TE.
  • Prospective studies are needed to investigate prophylactic anticoagulation and modifiable risk factors.

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