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Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Related Experiment Video

Updated: Jun 19, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

B cells in autoimmunity.

Thomas Dörner¹, Annett M Jacobi, Peter E Lipsky

¹Charite Center 12 and 14, Charite University Hospital and DRFZ Berlin, Chariteplatz 01, 10098 Berlin, Germany. thomas.doerner@charite.de

Arthritis Research & Therapy

|October 24, 2009

Summary

B cells, including plasmablasts and plasma cells, play dual roles in immune regulation. This review highlights their function in normal immunity and autoimmune diseases like lupus.

Area of Science:

Immunology
Cell Biology
Autoimmunity

Background:

B-cell development is a complex process involving regulated stages.
Recent advances have clarified B-cell effector functions and roles in autoimmune diseases.
B cells are increasingly recognized for their immunoregulatory potential.

Purpose of the Study:

To review the role of B-cell development stages, plasmablasts, and plasma cells in immune regulation.
To emphasize the involvement of these B-cell populations in systemic lupus erythematosus.
To discuss B cells as both effector and regulatory cells.

Main Methods:

Literature review of preclinical and clinical data.
Analysis of B-cell functions in normal and autoimmune conditions.

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Last Updated: Jun 19, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

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Published on: April 11, 2019

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Published on: December 1, 2023

Focus on systemic lupus erythematosus as a model autoimmune disease.

Main Results:

B-cell development stages are critical for immune homeostasis.
Plasmablasts and plasma cells exhibit significant effector functions.
B cells possess considerable immunoregulatory capabilities.

Conclusions:

B cells, at various developmental stages, are key players in immune regulation.
Dysregulation of B cells contributes to autoimmune diseases, notably lupus.
B cells represent promising targets for therapeutic interventions in autoimmunity.