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Aquaporins01:25

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Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
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Related Experiment Video

Updated: Jun 19, 2026

Reconstruction of the Blood-Brain Barrier In Vitro to Model and Therapeutically Target Neurological Disease
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Aquaglyceroporin 9 in brain pathologies.

J Badaut1

  • 1Departments of Pediatrics, Loma Linda University School of Medicine, 11175 Campus Street, Loma Linda, CA 92354, USA. jbadaut@llu.edu

Neuroscience
|October 24, 2009
PubMed
Summary
This summary is machine-generated.

Aquaporin 9 (AQP9) and aquaporin 4 (AQP4) have distinct roles in brain pathology. AQP4 impacts water homeostasis, while AQP9 may influence brain energy metabolism and lactate clearance in conditions like diabetes and stroke.

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Area of Science:

  • Molecular biology
  • Neuroscience
  • Cell biology

Background:

  • Aquaglyceroporins, like aquaporin 9 (AQP9), transport water and small solutes.
  • Aquaporin 4 (AQP4) is a water channel crucial for astrocyte water and ionic homeostasis.
  • Both AQP4 and AQP9 expression are altered in various pathological conditions.

Purpose of the Study:

  • To compare the expression patterns of AQP9 and AQP4 in pathological conditions.
  • To elucidate the distinct roles of AQP9 and AQP4 in neurological disorders.

Main Methods:

  • Literature review comparing AQP expression in pathological models.
  • Analysis of AQP4's role in brain disorders and cerebral edema.
  • Investigation of AQP9 expression in astrocytes and neurons under conditions like diabetes, stroke, and gliomas.

Main Results:

  • AQP4 expression is significantly modified in brain disorders, contributing to cerebral edema.
  • Brain AQP9 expression is influenced by insulin and increases in diabetes, suggesting a role in energy metabolism.
  • AQP9 is induced in astrocytes post-stroke, potentially aiding lactate clearance, and in other neuronal types and gliomas, though functions remain unclear.

Conclusions:

  • AQP4 and AQP9 exhibit distinct cellular localization and functional roles in the brain.
  • AQP9's involvement in brain energy metabolism and lactate clearance warrants further investigation.
  • Understanding cell-type-specific AQP functions is critical for deciphering their roles in neurological diseases.