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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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Related Experiment Video

Updated: Jun 19, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Progress towards a dengue vaccine.

Daniel P Webster1, Jeremy Farrar, Sarah Rowland-Jones

  • 1Department of Infectious Diseases and Microbiology, John Radcliffe Hospital, Oxford, UK. danwebster@doctors.org.uk

The Lancet. Infectious Diseases
|October 24, 2009
PubMed
Summary
This summary is machine-generated.

Developing a safe and effective dengue vaccine is crucial due to the virus

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Related Experiment Videos

Last Updated: Jun 19, 2026

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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Area of Science:

  • * Virology and immunology
  • * Tropical public health
  • * Vaccine development

Background:

  • * Dengue virus poses a significant global health threat, with 2.5 billion people at risk.
  • * Severe dengue involves complex virus-host interactions and immune mechanisms.
  • * Concerns about vaccine-induced enhancement of disease have slowed development.

Purpose of the Study:

  • * To review current understanding of dengue pathogenesis.
  • * To discuss implications for dengue vaccine design.
  • * To outline progress and challenges in dengue vaccine development.

Main Methods:

  • * Comprehensive literature review of dengue pathogenesis.
  • * Analysis of current dengue vaccine candidates and clinical trial data.
  • * Examination of immunological factors influencing vaccine efficacy and safety.

Main Results:

  • * A diverse pipeline of dengue vaccine candidates exists (live attenuated, inactivated, chimeric, DNA, viral-vector).
  • * Some candidates are progressing through clinical testing stages.
  • * Understanding pathogenesis is key to addressing safety concerns like antibody-dependent enhancement.

Conclusions:

  • * Safe and effective dengue vaccines are urgently needed to combat the growing public health crisis.
  • * Continued research into pathogenesis and vaccine-induced immunity is essential.
  • * Overcoming development challenges is critical for future dengue prevention strategies.