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Updated: Jun 19, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

[Antimicrobials and pregnancy].

Antonio Vallano1, Josep Maria Arnau

  • 1Servicio de Farmacología clínica, IDIBELL, Hospital Universitari de Bellvitge, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España. avallano@bellvitgehospital.cat

Enfermedades Infecciosas Y Microbiologia Clinica
|October 24, 2009
PubMed
Summary
This summary is machine-generated.

Pregnancy alters how the body processes antimicrobial drugs, affecting their efficacy and safety. This review examines available evidence on fetal toxicity risks of antibiotics, antifungals, antivirals, and antiparasitics during pregnancy.

Related Experiment Videos

Last Updated: Jun 19, 2026

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
04:18

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

  • Pharmacology
  • Maternal-Fetal Medicine
  • Infectious Diseases

Background:

  • Physiologic changes during pregnancy impact drug pharmacokinetics.
  • Pregnant women are often excluded from clinical trials, limiting drug data.
  • Antimicrobials can cross the placental barrier, posing potential risks to the fetus.

Purpose of the Study:

  • To review evidence on antimicrobial pharmacology in pregnancy.
  • To focus on fetal toxicity data for various antimicrobial classes.
  • To inform appropriate antimicrobial use and dosing in pregnant individuals.

Main Methods:

  • Literature review of available evidence.
  • Focus on clinical relevance and pharmacokinetic data.
  • Synthesis of information on antibiotic, antifungal, antiviral, and antiparasitic agents.

Main Results:

  • Pregnancy-induced pharmacokinetic changes can affect antimicrobial effectiveness.
  • Data on teratogenic and fetal/neonatal toxicity of antimicrobials is limited and variable.
  • Most antimicrobials cross the placenta, necessitating careful consideration of risks.

Conclusions:

  • Understanding antimicrobial pharmacology in pregnancy is crucial for safe and effective treatment.
  • Further research is needed to address data gaps regarding fetal safety.
  • Clinical decisions must weigh potential benefits against risks of antimicrobial exposure in pregnancy.