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Updated: Jun 19, 2026

Infant Auditory Processing and Event-related Brain Oscillations

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

Low-frequency EEG oscillations associated with information processing in schizophrenia.

Alan T Bates¹, Kent A Kiehl, Kristin R Laurens

¹Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. bates@interchange.ubc.ca

Schizophrenia Research

|October 24, 2009

Summary

People with schizophrenia show reduced delta and theta brainwave activity during cognitive tasks, despite increased activity at rest. This suggests impaired coordination of slow oscillations, potentially explaining brain region underactivation in schizophrenia.

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Area of Science:

Neuroscience
Psychiatry
Cognitive Science

Background:

Schizophrenia is linked to reduced amplitudes in event-related potential (ERP) components like P300 and Mismatch Negativity (MMN).
Functional magnetic resonance imaging (fMRI) studies often show decreased brain area activation in schizophrenia during tasks eliciting these ERPs.
Recent theories propose that phase-resetting of slow oscillations (delta and theta bands) underlies ERPs, with increased resting-state oscillations observed in schizophrenia.

Purpose of the Study:

To investigate event-related evoked and induced delta and theta activity in individuals with schizophrenia during cognitive tasks.
To compare these oscillations between people with schizophrenia and healthy controls.
To explore the relationship between slow-oscillation coordination and brain function in schizophrenia.

Main Methods:

Studied 17 individuals with schizophrenia and 17 healthy controls performing two variants of a go/no-go task.
Analyzed stimulus-related and response-related delta and theta oscillations.
Examined activity associated with correct-hits, correct-rejects, and false-alarms.

Main Results:

Individuals with schizophrenia exhibited reduced delta and theta activity during task-relevant events.
This pattern was observed across different task outcomes, including correct responses and errors.
Findings indicate a deficit in the coordination of low-frequency oscillations during cognitive processing in schizophrenia.

Conclusions:

Despite increased resting-state slow oscillations, schizophrenia is characterized by impaired event-related delta and theta activity coordination.
This abnormal coordination during information processing tasks may underlie the reduced brain area recruitment observed in fMRI studies of schizophrenia.
The findings highlight a potential neural mechanism contributing to cognitive deficits in schizophrenia.