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Updated: Jun 19, 2026
A Salt-Templated Synthesis Method for Porous Platinum-based Macrobeams and Macrotubes
Published on: May 18, 2020
Synthesis of new heterometallic macromolecules: their DNA binding, cleavage activity and in vitro model
Sartaj Tabassum1, Irshad-ul-Haq Bhat, Farukh Arjmand
1Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. tsartaj62@yahoo.com
Abstract:
The homodinuclear C(16)H(30)N(8)O(5)Sn(2)Cl(4) (1), heterotetranuclear C(16)H(38)N(8)O(9)Sn(2)Cu(2)Cl(8) (2) and C(16)H(38)N(8)O(9)Sn(2)Mn(2)Cl(8) (3) macrocyclic complexes were synthesized and characterized by elemental analysis, spectroscopic techniques and molar conductance measurements. The interaction studies of 1-3 with calf thymus DNA (CT-DNA) were carried out by UV-vis titration, fluorescence, cyclic voltammetry and viscosity measurements. These results were further authenticated by carrying out interaction studies of 1-3 with plasmid pBR322 DNA employing gel electrophoresis. To overcome the dose resistance, auto toxicity of the drugs, a model study based on electrochemotherapy (ECT) was carried out and the results were compared in the presence and in the absence of the applied electrical potential.
